022 CONCENTRATION CONTROLLED MYCOPHENOLATE DOSING IN RENAL TRANSPLANTATION IN INDIA
نویسندگان
چکیده
منابع مشابه
The impact of mycophenolate mofetil dosing patterns on clinical outcome after renal transplantation.
BACKGROUND Mycophenolate mofetil (MMF) has proven to be a very effective drug for the prevention of acute rejection following renal transplantation when dosed as prescribed at 2 or 3 g/d. However, circumstances arise in clinical transplantation where the dose must be lowered, either to avoid drug toxicity or because of concurrent infection. The impact on the incidence of acute rejection and gra...
متن کاملPharmacokinetics and Pharmacodynamics of Mycophenolate in Patients After Renal Transplantation
Mycophenolic-acid (MPA) is a selective, non-competitive inhibitor of InosineMonophosphate-Dyhydrogenase (IMPDH) leading to the inhibition of the de-novo synthesis of guanosine-nucleotides. In human lymphocytes inhibition of IMPDH results in altered cellular proliferation with arrest in the S-phase of the cell cycle. Due to the absence of a salvage pathway, proliferating activated t-cells are se...
متن کاملThe evolving role of mycophenolate mofetil in renal transplantation.
Mycophenolate mofetil (MMF) is an ester prodrug tial interest in organ transplantation is the inhibitory with higher bioavailability than the active agent, effect of MPA on the proliferation of human arterial mycophenolic acid (MPA).1 MPA inhibits inosine smooth muscle cells in vitro. Arterial disease plays monophosphate (IMP) dehydrogenase, an enzyme a central role in chronic graft rejection, ...
متن کاملEvaluation of tolerability of enteric-coated mycophenolate sodium versus mycophenolate mofetil in de novo renal transplantation.
INTRODUCTION Mycophenolate mofetil (MMF), pro-drug mycophenolic acid (MPA) is an immunosuppressive effective in the prophylaxis of acute rejection, but associated with gastrointestinal adverse events. Mycophenolate sodium (MPS) with enteric coating was developed with intention of reducing such gastrointestinal adverse events associated with MPA. OBJECTIVE To evaluate the tolerability of EC-MP...
متن کاملSeizure disorders after renal Transplantation in children
Background and Objective: Some neurologic complications may be detected after renal transplantation in children including tremor, peripheral neuropathy, altered level of consciousness and seizure. The aim of our study was to detect the prevalence of seizure after renal transplantation and its risk factors in pediatric age groups. Methods: In this descriptive study, 102 patients 5-14 yea...
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ژورنال
عنوان ژورنال: Indian Journal of Transplantation
سال: 2011
ISSN: 2212-0017
DOI: 10.1016/s2212-0017(11)60142-1